منابع مشابه
Chromosome Segregation: Reconstituting the Kinetochore
Faithful chromosome segregation is accomplished by attachment of chromosomes to spindle microtubules using the kinetochore. In a major step forward in understanding the functional and structural complexity of kinetochores, a 21-subunit human centromere - kinetochore complex has been reconstituted entirely from purified components, recreating the connection between DNA and microtubule.
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T he genomes of higher eukaryotes encode not only proteins but also diverse noncoding RNAs, particularly small (20to 30-nt) regulatory RNAs (1–3). The small RNAs include microRNAs (miRNAs), siRNAs, and piwi-interacting RNAs (piRNAs) (4, 5). These small RNAs repress gene expression at the transcriptional or posttranscriptional levels and have critical functions in genome defense, growth, develop...
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Calcium waves in membrane fusion hagolysosome fusion is a calcium dependent process. Now, Randall Worth and colleagues (University of Pennsylvania School of Medicine, Philadelphia, PA), and Howard Petty and colleagues (University of Michigan School of Medicine, Ann Arbor, MI) find that a three amino acid motif in the IgG receptor Fc RIIA causes a calcium wave traveling along the plasma membrane...
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The hematopoietic stem cell (HSC) compartment is composed of long-term reconstituting (LTR) and short-term reconstituting (STR) stem cells. LTR HSC can reconstitute the hematopoietic system for life, whereas STR HSC can sustain hematopoiesis for only a few weeks in the mouse. Several excellent gene expression profiles have been obtained of the total hematopoietic stem cell population. We have u...
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Most of the available SNP data have eluded valid population genetic analysis because most population genetical methods do not correctly accommodate the special discovery process used to identify SNPs. Most of the available SNP data have allele frequency distributions that are biased by the ascertainment protocol. We here show how this problem can be corrected by obtaining maximum-likelihood est...
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ژورنال
عنوان ژورنال: MRS Bulletin
سال: 2002
ISSN: 0883-7694,1938-1425
DOI: 10.1557/mrs2002.106